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The CETP polymorphism rs5882 is associated with triglyceride lowering in response to plant sterol consumption (1038.3)
Author(s) -
MacKay Dylan,
Eck Peter,
Baer David,
Jones Peter
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1038.3
Subject(s) - triglyceride , single nucleotide polymorphism , cholesterol , medicine , sterol , endocrinology , chemistry , lathosterol , crossover study , placebo , allele , zoology , biology , campesterol , biochemistry , gene , genotype , alternative medicine , pathology
Plant sterol (PS) consumption may lower triglyceride (TG) concentrations. However, human clinical trial evidence is inconsistent, with only some trials showing TG reductions. This heterogeneity in responsiveness of TG concentrations to PS consumption could have a genetic basis. Our objective was to investigate whether SNPs in genes related to TG metabolism could be associated with changes in TG concentrations following PS consumption. 63 mildly hypercholesterolemic adults, pre‐assessed for cholesterol synthesis using lathosterol to cholesterol ratio (L/C) (High, n=24, L/C = 2.03 ± 0.39 umol/mmol; Low, n=39, L/C =0.99±0.28 umol/mmol) consumed either 2g/d (free sterol) of PS ester or placebo in margarine for 28 d in a dual‐center, single‐blind, randomized, crossover design. Serum TG concentrations were measured at the end of each phase. Candidate SNPs and ApoE variant were accessed by TaqMan assay. PS consumption did not lower TG overall (p=0.0506), but had an interaction with rs5882 in CETP (p=0.0080). Homozygous minor allele (G/G=‐0.47mmol/L, p=0.0002, n=10) carriers of rs5882 had reductions in TG concentrations with PS consumption, while A/A (+0.01mmol/L, p =0.6634, n=25) and A/G (‐0.04mmol/L, p= 0.3399, n=28) carriers did not. rs5882 in CETP associated with TG lowering due to PS consumption, and could serve as a genetic marker to identify individuals who derive TG lowering benefits from PS consumption. Grant Funding Source : CIHR