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Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans (1037.7)
Author(s) -
Ma Yiyi,
Tucker Katherine,
Smith Caren,
Lee YuChi,
Huang Tao,
Lai ChaoQiang,
Parnell Laurence,
Richardson Kris,
Ordovas Jose
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1037.7
Subject(s) - waist , obesity , polyunsaturated fatty acid , lipoprotein lipase , body mass index , medicine , endocrinology , biology , fatty acid , biochemistry , adipose tissue
Lipoprotein lipase (LPL) is a candidate gene for obesity based on its role in metabolism of lipids and fatty acids. Our objective was to define the interaction between dietary fatty acids and LPL variants to modulate obesity traits. Based on known association with blood lipids and obesity, five single nucleotide polymorphisms (rs320, rs2083637, rs17411031, rs13702, rs2197089) were selected for the analysis in 1171 participants (333 men and 838 women, aged 45‐75 y) of the Boston Puerto Rican Health Study. rs320 interacted with dietary polyunsaturated fatty acids (PUFA) for body mass index (BMI) and waist circumference (WC), respectively, in both categorical (P=0.01 and 0.02) and continuous analysis (P=0.009 and 0.004). Higher intake of PUFA was associated with lower BMI and WC, respectively, in major allele homozygotes (TT) according to both categorical (P=0.03 and 0.01) and continuous analysis (P=0.01 and 0.004) but not in carriers of the minor allele (TG+GG). The other variants showed no such associations. To conclude, dietary PUFA interacted with LPL rs320 for anthropometric traits in a Puerto Rican population. These interactions may have implications for genotype‐based dietary recommendations for obesity prevention in US Hispanics. Grant Funding Source : P01AG023394, HL54776, DK075030, 53‐K06‐5‐10, 58‐1950‐9‐001