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The Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE) project (1034.19)
Author(s) -
Ashour Fayrouz,
Raiten Daniel
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1034.19
Subject(s) - inflammation , context (archaeology) , malnutrition , medicine , function (biology) , immune system , immunology , biology , pathology , paleontology , evolutionary biology
The Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE) project was a response to high prevalence of malnutrition, infectious and non‐communicable diseases. Of particular concern is the collision of these conditions in individuals and populations necessitating a deeper appreciation of the role of acute and chronic inflammation in the context of clinical assessment and population surveillance. INSPIRE was designed to provide an evidence based guidance to address the impact of inflammation on the selection, use and interpretation of nutrient biomarkers specifically and nutrition more broadly. Objective: To summarize the results of the INSPIRE project. Results: Four WG were constituted to address the continuum from basic biology to specific nutrition/inflammation relationships and potential approaches and methodologies to address these relationships. The WG addressed (1) the role of nutrition in immune function/inflammatory response, (2) the impact of nutrition on immune function/ inflammatory response and the impact of acute/chronic inflammation from either infection or NCD on nutrition, (3) Methodologies and new technologies, and (4) potential approaches to account for the impact of inflammation on nutrient assessment. The results of the WG deliberations will be presented as well as specific prioritized research gaps. Conclusion: The role of nutrition in immune function and the inflammatory process and vice versa is incontrovertible. The WG presented evidence of the nature of these relationships including the specific impact of acute and chronic inflammation resulting from both infection and NCDs. Specific suggestions are provided with regard to the relative strengths and weakness of approaches to accounting for these interactions. The value of systems biology incorporating a deeper understanding of the role of multiple nutrients within the immune/inflammatory systems are also explored. Grant Funding Source : Bill and Melinda Gates Foundation; NIH (NICHD and ODS)