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Overall effect of diet and supplementation with omega ‐3 fatty acids on the concentration of IL ‐6 and TNF‐α in obese adults (1034.17)
Author(s) -
DíazGutiérrez Mary Carmen,
TexcahuaSalazar Alejandra,
InturbideGarcía Mariana,
CharuaLevy Fredel,
ParraCarriedo Alicia,
HernándezGuerrero César
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1034.17
Subject(s) - medicine , proinflammatory cytokine , obesity , endocrinology , basal (medicine) , inflammation , insulin
Adequate dietary intervention in obesity is associated with decrease in proinflammatory factors by decreasing fat mass. The omega‐3 marine origin, have an antithrombotic and vasodilator effect, therefore play a role in cardiovascular disease to reduce the tendency to thrombus formation, platelet aggregation, blood viscosity, the presence of arrhythmias and the levels of inflammatory cytokines such as TNF‐α IL‐6. The American Heart Association recommends the consumption of 1g of omega‐ 3 per day, either through consumption of cold water fish or supplementation with capsules containing EPA and DHA. The objective was identify the effect of supplementation for 3 months with omega‐3 in conjunction with a dietary intervention on the concentration of IL‐6 and TNF‐α in obese adults. This is a quasi experimental clinical trial that included 29 adults with obesity according to BMI which received a diet according to the basal energy expenditure obtained by indirect calorimetry, with 55% carbohydrates, 20% protein and 25% lipids and supplemented by three months with 1.5g of omega ‐3 to 60% concentration per gram of fish. Determined basal and final weight, visceral fat mass and fat mass by bioimpedance and IL‐6 and TNF‐ α by ELISA. The results of the paired t‐ test showed a statistically significant difference in weight, BMI, body fat and visceral fat (P <0.05) as well as in levels of IL‐6 (20.6 ng/mL vs 12.7ng/mL; P <0.05). While the levels of TNF‐α showed no statistically significant difference after 3 months of therapy (10.0 ng/mL vs 7.2 ng/mL; P > 0.05). The significant weight loss at the expense of fat mass and omega‐3 supplementation significantly decreased the level of inflammation from the IL ‐6 in obese adults.