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Maternal high fat feeding alters bone lipid content at weaning without long‐lasting effects on bone lipid content and bone strength in male offspring at young adulthood (1033.7)
Author(s) -
Miotto Paula,
Castelli Laura,
LeBlanc Paul,
Peters Sandra,
Roy Brian,
Ward Wendy
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1033.7
Subject(s) - offspring , weaning , in utero , endocrinology , medicine , femur , lactation , polyunsaturated fatty acid , pregnancy , biology , zoology , fatty acid , fetus , surgery , biochemistry , genetics
High fat (HF) feeding after weaning results in elevated bone fatty acid content and reduced bone strength in growing rats and mice. However, the effect of a maternal HF diet to offspring in utero and during suckling is less characterized. Our study objective was to determine if maternal HF feeding altered male offspring bone lipid composition at weaning and 3 months of age, and if this was accompanied by lower bone strength. Female Wistar rats were fed either control (CON, 7% soybean oil by weight (TD.94045); n = 9) or HF (20% lard by weight (TD.02016); n = 9) diet for 10 weeks. Rats were bred and consumed their respective diets throughout pregnancy and lactation. All offspring were weaned to CON diet. At weaning, but not 3 months of age, percent mole fraction of polyunsaturated fatty acids were lower and monounsaturated fatty acids were higher in femur of offspring from dams fed HF diet than offspring of dams fed CON diet ( P <0.05). Peak load, the maximum force a bone withstands before fracture, was not different between groups at the femur (midpoint and neck) and 3 rd lumbar vertebra at 3 months of age. In conclusion, in utero and suckling exposure to a HF diet does not have long‐lasting effects on bone health in this rat model. Moreover, at 3 months of age, lipid composition of femurs no longer reflects maternal HF feeding and may explain why bone strength is similar between groups.