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High vitamin D and calcium intakes increase bone mineral content in diet‐induced obesity (1029.3)
Author(s) -
Song Qingming,
Sergeev Igor
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1029.3
Subject(s) - endocrinology , medicine , vitamin d and neurology , hydroxyproline , osteocalcin , chemistry , calcium , parathyroid hormone , bone resorption , bone remodeling , bone mineral , vitamin , osteoporosis , alkaline phosphatase , biochemistry , enzyme
Obesity can be detrimental to health of the growing bone, including an increased risk of bone fractures, because it is often associated with low vitamin D and calcium status. In this study, we determined effects of vitamin D and calcium supplementation on bone mineral content and blood biomarkers of Ca 2+ , vitamin D and bone metabolism in diet‐induced obese mice. Four‐week‐old male C57BL/6J mice were fed for 10 weeks either a high fat (HF) diet (60% energy from fat) or HF diets containing 1.2% Ca, 10000 IU/kg vitamin D 3 and their combination. The results obtained demonstrated that high Ca and vitamin D intakes increase bone Ca and P content and have no effect on bone collagen (hydroxyproline) content, as compared with the HF diet group. High vitamin D 3 intake significantly increased plasma concentrations of Ca 2+ , 25(OH)D, 1,25(OH) 2 D and decreased concentration of parathyroid hormone (PTH) and osteocalcin in HF diet‐fed mice. High Ca intake suppressed PTH but also increased plasma Ca 2+ . These findings suggest that the vitamin D and Ca supplementation improves bone status in obesity by increasing bone mineralization and, probably, suppressing bone resorption via PTH/1,25(OH) 2 D axis. Grant Funding Source : Supported by USDA 2009‐35200‐05008 and SD00H325 to I.N.S..