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Effects of aerobic or resistance exercise training in the management of genetic predisposition to obesity (1028.6)
Author(s) -
Sartori Michelle,
Santos Fernando,
De Angelis Katia,
Irigoyen Maria
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1028.6
Subject(s) - medicine , aerobic exercise , blood pressure , heart rate , baroreflex , treadmill , endocrinology , cardiology
The aim of this study was to compare aerobic and resistance exercise training effects on, metabolic and autonomic parameters in youth obese mice. Female ob/ob mice (4 weeks) were randomized into: sedentary (OS, n=11), aerobic trained (OA, n=8) (treadmill,5 days/w, 60 min/d, during 8 wks) and resistance trained (OR, n=8) (ladder climb, 5 days/w, during 8 wks) groups. Blood glucose Glucose tolerance test and glycemia were evaluated. Blood pressure (BP) signals were directly recorded using a data acquisition system. The OA and OR groups had higher treadmill exercise capacity (TT) and maximum strength test (ladder) (ST) than the OS group. However, the OA showed increase in TT in relation to the OR animals, as well as the OR showed greater strength compared OA group. OA and OR groups had reduced body weight and blood glucose (OA:45±2g and 133±3mg/dL, OR: 46±1g and 155±9mg/dL) compared to OS group (50±2g and 169±8mg/dL). Mean BP and heart rate were similar between groups. The trained groups showed an increase in cardiac parasympathetic modulation (pulse interval variance and RMSSD) compared with sedentary mice. The BP variability and the low frequency band of BP were higher in the OS (30±2 and 9±1mmHg2) compared to the OA (14±2 and 5±1mmHg2) and OR (15±2 and 5±1mmHg2) groups. Moreover, the spontaneous baroreflex sensitivity, represented by alpha index, was lower in the sedentary group (1.2±0.3 ms/mmHg) compared to the trained groups (OA:1.9±0.2, OR:2.2±0.6ms/mmHg). Thus, our results suggest that physical training during lifespan, regardless of resistance or aerobic exercise, can be effective in attenuating the metabolic and autonomic dysfunctions associated with obesity in mice. Grant Funding Source : Supported by FAPESP 2011/20859‐0