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Impact of exercise and/or beta‐alanine and epigallocatechin gallate on muscle function and oxidative stress in aged mice (1027.2)
Author(s) -
Pence Brandt,
Gibbons Trisha,
Bhattacharya Tushar,
Mach Houston,
Ossyra Jessica,
McCusker Robert,
Kelley Keith,
Rhodes Justin,
Johnson Rodney,
Woods Jeffrey
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1027.2
Subject(s) - oxidative stress , endocrinology , medicine , epigallocatechin gallate , treadmill , sed , gastrocnemius muscle , sod2 , antioxidant , chemistry , skeletal muscle , superoxide dismutase , biochemistry , polyphenol
Exercise improves muscle function and oxidative stress in the elderly. Several dietary interventions have been evaluated for their effects. Beta‐alanine (BA) improves muscle function, while epigallocatechin gallate (EGCG) is an antioxidant. Little is known about the interaction between exercise and diet. We examined the effects of voluntary wheel running (VWR) and/or supplementation with BA and EGCG on muscle function and oxidative stress in aged mice. Control diet (CTRL) or diet supplemented with 1.5 mg/g EGCG and 3.43 mg/g BA was given ad lib. to 17 month old male Balb/c mice for 4 weeks, during which they ran on a wheel or remained sedentary (SED). Mice then underwent muscle function tests over 11 days, and were euthanized 24 hours after the final test for tissue collection. Mice were maintained on diet and exercise interventions during the 11 day period. Diet and VWR did not differ in impact on body weight, food intake, or body composition. VWR maintained strength (p=.027) and improved performance on a treadmill (p=.001). VWR increased Nos2 and Sod2 gene expression in the gastrocnemius. There was a diet × VWR interaction (p=.012) such that the CTRL/SED group had non‐significantly increased gastrocnemius 4‐HNE levels compared to the other 3 groups. In conclusion, VWR but not a diet supplemented with BA and EGCG increased muscle function, whereas both VWR and BA/EGCG tended to reduce oxidative stress in aged muscle. Grant Funding Source : Supported by a grant from Abbott Nutrition.