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The effects of freeze‐dried mango on bone parameters of ovariectomized mice (1025.9)
Author(s) -
Eldoumi Heba,
Meister Maureen,
Peterson Sandra,
KetzRiley Connie,
PerkinsVeazie Penelope,
Stephen Clarke,
Smith Brenda,
Lucas Edralin
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1025.9
Subject(s) - ovariectomized rat , osteoporosis , medicine , population , tibia , ascorbic acid , endocrinology , estrogen , chemistry , food science , surgery , environmental health
Osteoporosis is a major problem worldwide particularly in postmenopausal women. Interest is growing in dietary alternatives, such as fruits and vegetables, in treating and/or preventing osteoporosis in this population. Mango is an excellent source of dietary antioxidants, such as ascorbic acid, carotenoids, and phenolic compounds, which can play a role in maintaining bone health. The objective of this study was to investigate the effects of two doses of mango and its polyphenol (PP) in preventing bone loss in ovariectomized (Ovx) mice, a model of postmenopausal osteoporosis. Ninety, female three‐month‐old C57/ BL6 mice were either sham‐operated or Ovx and were randomly assigned to one of the following treatment groups for ninety days (n=12/group): (a) Sham+control, (b) Ovx+control, (c) Ovx+1% or 10% (w/w) freeze‐dried mango or mango PP diet (equivalent PP to that of 1 and 10% mango), and (d) Ovx+alendronate (ALN) injection (1 ug/kg body weight). All diets were isocaloric, isonitrogenous and had the same calcium and phosphorus concentrations. Mango slightly improved trabecular microarchitectural parameters of the lumbar bone but not the tibia. As expected, Ovx decreased lumbar trabecular bone volume, number, connectivity density, and increased trabecular separation and structure model index. These microarchitectural parameters were improved by both doses of PP and the 10% mango to a similar extent as the Ovx+ALN group, but were not different from the Ovx+control group. Our results suggest that mango supplementation may promote the maintenance of skeletal health in estrogen deficiency through its effects on trabecular bone.