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Rapid weight gain through age 4 y is associated with increased adiposity, higher blood pressure and insulin alterations at 4‐5 y (1024.14)
Author(s) -
RamírezSilva Claudia,
RiveraDommarco Juan,
TrejoValdivia Belem,
Martorell Reynaldo,
Stein Aryeh,
Ramakrishnan Usha,
Romieu Isabelle,
BarrazaVillarreal Albino
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1024.14
Subject(s) - medicine , blood pressure , breastfeeding , anthropometry , insulin , confounding , endocrinology , pregnancy , weight gain , body mass index , placebo , body weight , pediatrics , biology , genetics , alternative medicine , pathology
To evaluate the relationship between rapid weight gain (RWG) in selected periods between 1‐48 mo with adiposity, blood pressure and insulin levels at 4‐5 y of age, we studied 449 offspring of Mexican women who participated in a randomized trial in which women were supplemented with 400 mg/d DHA or placebo from mid‐pregnancy to parturition. Insulin from non‐fasting blood was obtained at 4 y, and anthropometry and blood pressure were obtained at 5 y. RWG was defined as an increase of 蠅+1.0 Z‐score weight‐for‐height within the age periods 0‐6, 6‐12, 12‐24 and 24‐48 mo. We used multivariate multiple linear models, with adjustment for DHA treatment and confounding variables (socioeconomic level, BMI of the mother during pregnancy, maternal schooling, breastfeeding at 3mo, hours of fasting, sex and height of the child). Relative to children without RWG, those with RWG at each period had higher BMI (differences ranged from 0.42 to 0.89Kg/m2; all p <0.01), sum‐of‐skinfold (range 1.1 to 3.6mm; all p<0.01) and abdominal circumference (range 1.2 to 3.8 cm; all p<0.01) at 5 y; RWG in any period from 6‐48 mo was associated with higher systolic and diastolic blood pressure (ranges 1.2 to 1.8 mmHg and 0.9 to 1.2 mmHg; all p<0.05, respectively) at 5 y. RWG in any period from 12‐48 mo was associated with 13% higher insulin levels (p<0.05) at 4 y. Children with RWG during the first 4 y had higher risk of adiposity and cardiometabolic alterations at 4‐5 y. Grant Funding Source : NIH (HD058818; HDO43099), Mexico (CONACYT Grant number SALUD‐2008‐01‐87121).