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Drug susceptibility influences macronutrient intake and body composition in tuberculosis patients (1014.4)
Author(s) -
Frediani Jennifer,
Tukvadze Nestan,
Sanikidze Eka,
Kipiani Maia,
Hebbar Gautam,
Tangpricha Vin,
Blumberg Henry,
Ziegler Thomas
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1014.4
Subject(s) - medicine , bioelectrical impedance analysis , wasting , lean body mass , placebo , cohort , fat mass , physiology , anabolism , body mass index , endocrinology , body weight , pathology , alternative medicine
Background: Malnutrition and lean tissue wasting are common in patients with tuberculosis (TB) disease, yet little information is available on habitual dietary intake or links with body composition. Methods: Dietary intake was obtained in a randomized clinical trial of high‐dose vitamin D (Vit D) in patients with pulmonary TB in Tbilisi, Georgia. Food intake was obtained (0, 8 and 16 weeks) using a validated, culture‐specific tool. Serial body composition was by BMI and bioelectrical impedance analysis (BIA; % fat mass and % fat‐free mass). Descriptive statistics and repeated measures ANOVA were used. Results: 192 subjects (mean age 35 y; 100 Vit D, 99 placebo) were studied. Mean daily intake of kcal, fat and protein were adequate at diagnosis and increased (with BMI) over time (time effect p<0.0001, treatment effect NS). There were no differences in % of fat mass or % fat‐free mass between groups over time. Multi‐drug resistant TB patients (n=23) had lower body weight, BMI (p=0.05) and fat‐free mass vs. drug‐susceptible patients, despite increased intake of kcal, protein, fat and CHO at 8 and 16 weeks. Conclusions: Macronutrient intake was adequate in this TB patient cohort. Increased macronutrient intake occurred concomitant with increased BMI and maintained proportions of body fat and fat‐free mass. MDR‐TB patients demonstrated less efficient anabolism than drug‐susceptible TB patients. 1 Grant Funding Source : Supported by grants from the National Institutes of Health Fogarty grant D43 TW007124 and K24 RR0233