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Distribution of Electrical Activation to Parasternal Intercostal Muscles during High Frequency Spinal Cord Stimulation (HF‐SCS)
Author(s) -
DiMarco Anthony F.,
Kowalski Krzysztof E.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb871
Subject(s) - parasternal line , intercostal muscle , spinal cord , breathing , medicine , stimulation , anatomy , motor unit , cardiology , anesthesia , respiratory system , psychiatry
Objective HF‐SCS is a novel technique of inspiratory muscle activation involving stimulation of spinal cord pathways. The purpose of the present study was to compare the spatial distribution of motor drive to the parasternal intercostal (PS) muscles during spontaneous breathing with that occurring during HF‐SCS. Methods In 6 anesthetized dogs, HF‐SCS was applied at the T2 spinal level. Fine wire recording electrodes were used to assess single motor unit (SMU) pattern of activation in the medial portions of the 2nd (PS‐2M) and 4th (PS‐4M) and lateral portion of the 2nd (PS‐2L) interspaces during spontaneous breathing and HF‐SCS following C1 spinal section. Results During HF‐SCS mean peak SMU firing frequency was highest in the PS‐2M (13.3±0.4Hz) and significantly lower in the PS‐2L (8.8±0.2Hz) and PS‐4M (11.4±0.3Hz) (p<0.05 for each comparison). Similar rostrocaudal and dorsoventral gradients of activity were observed during spontaneous breathing prior to C1 section. Conclusion This study demonstrates that: a) the topographic pattern of electrical activation of the parasternal intercostal muscles during HF‐SCS is similar to that occurring during spontaneous breathing and b) differential descending synaptic input from supraspinal centers is not a required component of the differential spatial distribution of parasternal intercostal activation. Support: NIH‐NINDS (R01NS064157)