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Different hemodynamic responses of normotensive and hypertensive rats to intracerebroventricular infusion of NaHS
Author(s) -
Sikora Mariusz,
Jodlowska Maria,
Kolaszynska Katarzyna,
Ufnal Marcin
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb848
Subject(s) - sodium hydrosulfide , blood pressure , medicine , hemodynamics , endocrinology , homeostasis , mean arterial pressure , heart rate , anesthesia , chemistry , hydrogen sulfide , sulfur , organic chemistry
Hydrogen sulfide (H 2 S) has been found to be involved in the regulation of the circulatory system. Previously, we found that intracerebroventricular (icv) infusion of sodium hydrosulfide (NaHS), a H 2 S donor, evokes hypertensive response in normotensive rats. Here, we checked hemodynamic effects of icv infusions of NaHS in hypertensive rats. We measured mean arterial blood pressure (MABP) in male spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats at baseline and during 45 min of icv infusions of either vehicle (Krebs‐Henseleit bicarbonate‐buffer) or NaHS solution at a dose of 30, 100 and 300 nmol/h. ICV infusions of vehicle did not cause significant changes in MABP. WKY rats infused with 30 nmol of NaHS showed mild hypotension, whereas the infusion of 100 nmol caused hypotension followed by an increase in MABP. NaHS at a dose of 300 nmol produced a hypertensive response. In contrast, SHR rats infused with all the tested doses of NaHS showed a decrease in MABP in a dose‐dependent manner. The results support our previous findings that H 2 S is involved in the neurogenic control of blood pressure. Furthermore, this study shows that hypertensive rats have altered responsiveness to H 2 S, which may suggest disturbances in H 2 S homeostasis in the brain of hypertensive animals. This work was supported by the National Science Center, grant 3G29 and Medical University of Warsaw, grant 1MA/PM11/12.