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Eccentric exercise‐induced inflammatory response is augmented in type II diabetic skeletal muscle
Author(s) -
SUDO MIZUKI,
Eshima Hiroaki,
Ando Soichi,
Kano Yutaka,
Tanaka Hiroaki,
Higaki Yasuki
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb826
Subject(s) - skeletal muscle , inflammation , medicine , endocrinology , eccentric , type 2 diabetes , stimulation , diabetes mellitus , regeneration (biology) , tibialis anterior muscle , biology , microbiology and biotechnology , physics , quantum mechanics
Type II diabetes mellitus induces peripheral circulatory failure, neuropathy, and diabetic myoatrophy. Recent studies have shown that resistance exercise seems to be effective for maintaining muscle mass in type II diabetic patients. On the other hand, eccentric exercise (ECC) has the potential to induce severe muscle inflammation and damage, which may lead to physical inactivity. However, it is unclear whether inflammation‐regeneration response occurs in type II diabetic skeletal muscle in a similar manner as the normal one. The aim of the present study was to examine inflammation‐regeneration response after ECC in type II diabetic skeletal muscle. In anesthetized Wistar (NM) and Goto‐Kakizaki (T2D) rats, the tibialis anterior muscles were subjected to 40 times‐repeated ECC, which was evoked by surface electric stimulation with mechanical muscle stretch. The inflammatory response was examined at 1, 3, 7 and 14 days after ECC. The regenerated fibers with central nucleus were detected at 7 and 14 days after ECC. The average peak torque during ECC was significantly lower in the T2D (5.9 ± 3.7 mNm) than in the NM (11.1 ± 5.2 mNm). The inflammatory responses were significantly increased in the T2D (day 1: 14.8 ± 4.8%, day 3: 35.6 ± 7.0%) compared with the NM (day 1: 6.2 ± 2.5%,day 3: 29.6 ± 12.3%, p < 0.05, respectively). Furthermore, the regeneration fibers with central nuclei were observed at day 7 and 14 in the NM. However, we detected the regeneration fibers with central nuclei only at day 14 in the T2D. In conclusion, inflammatory response induced by mechanical stress is augmented in type II diabetic skeletal muscle as compared with normal one. This study was supported in part by a Grant‐in‐Aid for young Scientists (B).