Premium
Arctigenin improves glucose metabolism in line of mighty mice
Author(s) -
Bawany Mohammad Husain,
Savage Kathleen
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb805
Subject(s) - endocrinology , medicine , ampk , carbohydrate metabolism , skeletal muscle , muscle hypertrophy , glucose uptake , chemistry , metabolism , biology , protein kinase a , kinase , insulin , biochemistry
Many transforming growth factor β (TGFβ) protein family members signal through the activin receptor IIB in order to impact skeletal muscle. Mice expressing a muscle specific dominant negative activin receptor IIB (dnActRIIB) have muscle hypertrophy, increased lean mass, decreased fat mass, improved glucose metabolism on standard and high‐fat diets, and resistance to diet‐induced obesity. It has recently been discovered that AMPK activation can lead to endurance training like adaptations. The current study examined the ability of Arctigenin, an herbal extract known to activate adenosine monophosphate kinase (AMPK), to change glucose metabolism in dnActRIIB mice. Wildtype and dnActRIIB mice were treated with Arctigenin or saline 5 days per week for 6 weeks. Mice were fasted overnight and a standard intraperitoneal glucose tolerance test was conducted. Treatment with Arctigenin did not alter glucose disposal in wildtype mice. However, Arctigenin treatment improved glucose disposal in dnActRIIB mice. Arctigenin treatment did not alter body weight or muscle weights, and ongoing studies are being performed to determine if Arctigenin stimulates muscle plasticity.