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Voluntary exercise at young stage prevents glucose intolerance in type 2 diabetic rats
Author(s) -
Tsuzuki Takamasa,
Yoshihara Toshinori,
IchinosekiSekine Noriko,
Kobayashi Hiroyuki,
Naito Hisashi
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb755
Subject(s) - medicine , endocrinology , diabetes mellitus , carbohydrate metabolism , type 2 diabetes , area under the curve , glucose tolerance test , sed , turnover , wheel running , chemistry , insulin resistance , management , economics
Purpose To investigate the effects of voluntary exercise at young stage on whole‐body metabolism and glucose tolerance in type 2 diabetic rats. Methods Otsuka Long‐Evans Tokushima Fatty (OLETF) rats as an animal model of type 2 diabetes and their counterparts (Long‐Evans Tokushima Otsuka; LETO) were used. Twenty male OLETF and LETO rats were divided into three groups, respectively: Sedentary (SED, n=8), Wheel Running (WR, n=6), or Wheel Running‐Sedentary (WS, n=6) group. WR and WS groups were allowed to access a running wheel freely from 5 to 25 week‐old. In WS group, however, a running wheel was locked from 15 to 25 week‐old and rats could not run in the wheel. At 25 week‐old, resting oxygen consumption (VO2 rest) of each rat was measured in a metabolic chamber. Subsequently an intraperitoneal glucose tolerance test (IPGTT) was performed. Results There were no significant differences in the areas under the curve of IPGTT (AUC) and VO2 rest (ml/kg/min) among three LETO groups. In OLETF rats, AUC in WR and WS groups were significantly lower than SED group, with AUC being lower for WR group. Moreover, VO2 rest of OLETF in WR and WS groups were significantly higher than SED group. Conclusion Our data suggest that voluntary exercise at young stage improves resting metabolism and prevents glucose intolerance in grown‐up type 2 diabetic rats, and these effects remained following exercise cessation.