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Estrogen and progesterone do not mediate the attenuated febrile response to E. coli LPS in rats near the term of pregnancy
Author(s) -
Finley Caitlin R,
Fewell James E.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb744
Subject(s) - pregnancy , medicine , endocrinology , estrogen , basal (medicine) , hormone , lipopolysaccharide , core (optical fiber) , chemistry , biology , genetics , materials science , insulin , composite material
The febrile response to LPS is attenuated in rats near the term of pregnancy at a time when plasma concentrations of estrogen (E) and progesterone (P) are elevated. In an attempt to clarify mechanisms, the present experiments were carried out on chronically‐instrumented, conscious rats to test the hypothesis that elevated plasma concentrations of E and P similar to that observed near the term of pregnancy would attenuate the febrile response to LPS in non pregnant rats (NP). NP and oophorectimized rats received intraperitoneal vehicle (V) or E, P, E+P over 3.5 days in amounts sufficient to produce plasma concentrations observed near the term of pregnancy. Core temperature was recorded via radio telemetry. Hormone treatment did not alter basal core temperatures nor the core temperature responses to an EC 50 dose of E. coli LPS. Thus, our data do not support the hypothesis that elevated plasma concentrations of E & P mediate the attenuated core temperature responses to LPS in rats near the term of pregnancy.