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Losartan prevents impairment of learning and memory induced by chronic mild and unpredictable stress in rats
Author(s) -
Sanches Andrea,
Casarini Dulce Elena,
Marcondes Fernanda Klein,
Cunha Tatiana Sousa
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb729
Subject(s) - losartan , medicine , memory impairment , analysis of variance , angiotensin ii , receptor , cognition , psychiatry
We have previously shown that chronic mild and unpredictable stress (CMS) reduced learning and memory and increased renin‐angiotensin system (RAS) activity in rats. The aim of this study was to evaluate the effect of RAS inhibition on the stress induced‐learning and memory‐impairment in rats. Male Sprague‐Dawley rats were randomized into four groups: control, CMS, losartan (50mg/Kg) and CMS + losartan (n=12/group). CMS protocol consisted on application of different stressors, 7 days/week during 3 weeks. Fifteen days after CMS the Y‐maze test was performed for learning and memory evaluation. Data were analyzed by bifatorial ANOVA (p<0.05). All procedures were approved by Institutional Ethics Committee. There was a decrease in difference scores of entries on CMS group (3.0 ± 4.5%) compared with control group (21.9 ± 4.6%) and CMS + losartan group (18.0 ± 2.7%) compared to losartan group (26.7 ± 5.1). Losartan and CMS + losartan groups showed increased of entries difference score compared with control and CMS respectively. There was no difference between control and CMS + losartan group. These data suggest that RAS overactivity is at least in part involved in learning and memory impairment induced by CMS. Financial support: FAPESP, CNPq, CAPES.