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Enhanced thrombus development after transient cerebral ischemia
Author(s) -
Tang Ya Hui,
Granger D. Neil
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb691
Subject(s) - thrombus , medicine , cardiology , ischemia , cerebral infarction , aspirin , stroke (engine) , thrombosis , microcirculation , middle cerebral artery , infarction , anesthesia , myocardial infarction , mechanical engineering , engineering
Transient ischemic attack (TIA) is a precursor event in 7–40% of patients who suffer from an ischemic stroke. This study examined whether a brief transient period of ischemia leads to an increased vulnerability of the brain to thrombus development. TIA were induced in mouse brain by occluding the middle cerebral artery for 2.5 to 10 mins. Twenty‐four hrs thereafter, mice were evaluated for neurological deficits, and thrombus formation was induced in cerebral microvessels using the light/dye method. Thrombosis was quantified using time of onset of platelet aggregation on the vessel wall and time to complete flow cessation. Compared to control mice, TIAs ranging in duration from 2.5 to 10 mins resulted in an accelerated rate of thrombus development. The TIA enhanced thrombogenesis was not accompanied by changes in neurological function or brain infarction (assessed by TTC staining). Aspirin (ASA), which is an initial line of treatment for TIA in humans, was shown to offer modest but significant protection against TIA enhanced thrombus development. Our findings indicate that TIA accelerates thrombus development in the cerebral microcirculation and that ASA treatment offers modest benefit in preventing this response.