Premium
Iron‐dependent regulation of mitochondrial form and function
Author(s) -
Jeevananthan Athavi,
Rensvold Jarred W.,
Ong ShaoEn,
Carr Steven A.,
Mootha Vamsi K.,
Pagliarini David J.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb65
Subject(s) - mitochondrion , microbiology and biotechnology , biogenesis , function (biology) , mitochondrial biogenesis , biology , iron homeostasis , adaptation (eye) , metabolism , biochemistry , gene , neuroscience
Mitochondria play vital roles in cellular metabolism and signaling, and their composition and function must change in response to environmental conditions and nutrient demands. However, the signals that initiate this mitochondrial adaptation remain largely unclear. Our matched genomic and proteomic analyses reveal that proteins involved in iron homeostasis are highly coordinated with mitochondrial biogenesis and that iron deprivation alone results in a systematic loss of mitochondrial transcripts and proteins. Moreover, we determined that the reintroduction of iron to iron‐deprived cells resulted in the complete recovery of mitochondrial transcripts, proteins and respiratory function. This indicates that our observed mitochondrial response to iron deprivation is a calibrated adaptive response and not merely irreversible cellular damage. Taken together, our results reveal that iron deprivation drives a widespread, adaptive transformation of mitochondrial form and function. This research was supported by a Searle Scholars Award, and grants from the NIH and USDA.