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Amomum subulatum (Roxb.) seeds extract ameliorates paracetamol‐induced hepatoxocicity in rats
Author(s) -
Parmar Mihir Y.,
Shah Purvi A.,
AlRejaie Salim S,
AlHosaini Khaled A,
Gandhi Tejal R
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb639
Subject(s) - malondialdehyde , catalase , alkaline phosphatase , glutathione , oxidative stress , chemistry , pharmacology , superoxide dismutase , alanine aminotransferase , biochemistry , enzyme , medicine
This study was designed to evaluate the Hepatoprotective activity of methanolic extract of Amomum subulatum seeds (MEAS) against paracetamol (3 g/kg, p.o. for 3 days) induced liver damage in rats using silymarin as standard. The degree of protection was estimated by measuring serum levels of alanine aminotransferas (ALT) and aspartate aminotransferas (AST), alkaline phosphatase (ALP), Moreover, biomarkers for oxidative stress such as malondialdehyde (MDA), reduced glutathione (GSH), super oxide dismutase (SOD) and catalase (CAT) were estimated in hepatic tissues. Significant higher levels of above serum biomarkers were observed in paracetamol control as compared to normal control. Treatments with MEAS and silymarin significantly inhibited paracetamol induced elevation in ALT, AST and ALP serum levels. Furthermore, there was a significant increase in MDA while decrease in GSH level, SOD and CAT activities in paracetamol group as compared to control animals. Again, treatment of the animals with MEAS and silymarin brought these stress parameters changes significantly towards normal levels as compared to paracetamol control group. These results suggest that MEAS may have potential therapeutic value to reduce the severity of paracetamol induced liver damage, probably by its antioxidative effect on liver by eliminating the deleterious effects of toxic metabolites of paracetamol.