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Histological studies on the hazardous effects of ethanol on liver and sple en in Swiss albino mice
Author(s) -
ALDAHMASH BADR
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb538
Subject(s) - spleen , ethanol , liver injury , medicine , pathology , physiology , chemistry , biochemistry
Considering that ethanol caused number of health problems in the world, the present study was initiated to investigate the histological hazardous effects of ethanol on the liver and spleen. Animals were divided into 4 groups, the first group served as a control group, the second, third and fourth received 1,2 and 6 ml/kg/bw of 70% ethanol respectively. At the day 5 post treatment, the liver and spleen sections were prepared for the histological study. Ethanol intake induced marked histologyical alterations in the liver and spleen that correlated with the dose taken, low dose induced liver and spleen injury mainly as cytoplasmic degeneration in liver and abnormal structure of spleen, whereas, high doses of ethanol resulted in fibrosis in liver and splenomegaly.