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Effects of Minocycline on Oxycodone‐Induced Responses in Humans
Author(s) -
Mogali Shanthi,
Comer Sandra D.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb530
Subject(s) - oxycodone , minocycline , opioid , abuse liability , pharmacology , anesthesia , medicine , drug , chemistry , biochemistry , receptor , antibiotics
Preclinical studies suggest that inhibition of glial activation with minocycline (MINO) modulates opioid‐induced responses while preserving opioid analgesia. This study assessed the effects of minocycline on the abuse liability of oxycodone in humans. Non‐dependent opioid abusers (N=7) participated in this randomized, double‐blind outpatient study. Subjects completed five sessions in which they received 0, 100, or 200 mg MINO with either 0 or 40 mg oxycodone (OXY). Subjective and physiological effects of OXY were measured before and repeatedly after drug administration. Results show MINO did not alter the physiological effects of OXY. Compared to PBO MINO, MINO 200 mg+ OXY 40 mg significantly reduced ratings of “High” (p< 0.05). Both MINO 100 and 200 mg administered in combination with OXY 40 mg significantly reduced ratings of “Good Effect” and delayed the peak rating of “Good Effect” by 60 minutes compared to OXY alone (p<0.05). MINO 100 and 200 mg in combination with OXY 40 mg significantly reduced drug “Liking” compared to OXY alone (p< 0.05). Ratings of drug “liking” of OXY 40 mg when combined with either MINO 100 mg or 200 mg were comparable to PBO OXY. Participants reported that they “Would Pay” significantly less for MINO 200 mg + OXY 40 mg than OXY alone (p<0.001). These results demonstrate that MINO robustly attenuated the positive subjective effects of OXY in recreational opioid abusers.