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The Best Way to Improve HDL is to Lower LDL Levels.
Author(s) -
Vakili Ladan,
Khany Mitra,
Karimi Nika,
Vazirian Samra,
Gapele Ania
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb498
Subject(s) - paraoxonase , medicine , cholesterol , high density lipoprotein , aryldialkylphosphatase , pon1 , endocrinology , lipoprotein , oxidative phosphorylation , population , cardiology , oxidative stress , chemistry , biochemistry , environmental health , gene , genotype
Objective Analyses of HDL function. Introduction Population studies have shown that plasma levels of HDL (high density lipoprotein) inversely correlate with the prevalence of coronary heart disease. Plasma HDL cholesterol levels in an individual however, does not necessarily correlate with the risk for coronary heart disease. Many patients with high HDL, present with coronary events and many individuals with low HDL cholesterol do not develop coronary complications. Our group previously demonstrated that HDL composition and function could be more important than HDL cholesterol levels. Under excessive inflammatory pressure unsaturated fatty acids in HDL can undergo oxidative modification. Protective enzymes including paraoxonase, LCAT and PLTP can be inactivated by oxidative modification reducing HDL's anti inflammatory properties. This results in HDL not being able to protect LDL from oxidative modification. Methods Fasting plasma from patients with documented coronary disease were analyzed for their ability to prevent LDL modification. Results We demonstrated that among coronary patients over 69 per cent had non protective HDL while among healthy controls 4.5 per cent had dysfunctional HDL. Conclusion While there are effective medications for lowering LDL cholesterol (namely statins) there are few or no satisfactory drugs for raising HDL levels.