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Moderate intensity exercise does not modulate myostatin and follistatin gene expression in the gastrocnemius muscle of spontaneously hypertensive rats with heart failure
Author(s) -
Damatto Ricardo Luiz,
Pagan Luana,
Lima Aline,
Cezar Marcelo,
Martinez Paula,
Bonomo Camila,
Guizoni Daniele,
Gomes Mariana,
Okoshi Katashi,
Okoshi Marina
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb484
Subject(s) - myostatin , follistatin , medicine , endocrinology , heart failure , gastrocnemius muscle , aerobic exercise , analysis of variance , anaerobic exercise , cardiology , skeletal muscle , physical therapy
The myostatin/follistatin pathway modulates skeletal muscle trophism. Physical exercise has an important role in the heart failure treatment. In this study we evaluated the effects of moderate aerobic physical training on myostatin and follistatin gene expression and trophism in the gastrocnemius of spontaneously hypertensive rats with heart failure. Sixteen‐month‐old SHRs and normotensive Wistar‐Kyoto (WKY) rats were assigned to sedentary or trained groups. Exercise was performed on treadmill, 30 min/day, 5 days/week, 12 m/min for 4 months. Transthoracic echocardiogram was performed at the end of experiment. Gene expression was evaluated by real time RT‐PCR. Fiber cross‐sectional area was measured in HE‐stained histological sections. Statistical analysis two‐way ANOVA and Tukey. Results Echocardiography showed left cardiac chambers dilation and left ventricular systolic and diastolic dysfunction in both SHR groups compared to the WKY groups. Gene expression of myostatin and follistatin did not differ between groups. Cross‐sectional area was reduced in both SHR groups compared to WKY and was not changed by exercise. Conclusion Physical exercise does not modulate skeletal muscle trophism and myostatin and follistatin gene expression in spontaneously hypertensive rats with heart failure.