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Pigment epithelium‐derived factor ameliorates noise damage to the intra‐strial fluid‐blood barrier
Author(s) -
Shi Xiaorui,
Zhang Fei,
Neng Lingling,
Zhang Jinhui,
Jiang Meiyan
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb432
Subject(s) - pedf , tight junction , inner ear , vascular permeability , claudin , pathology , medicine , edema , chemistry , microbiology and biotechnology , biology , anatomy , angiogenesis
A unique endothelial‐blood/tissue barrier in the inner ear, termed the “intra‐strial fluid‐blood barrier,” is critical for maintaining cochlear homeostasis. Disruption of the barrier is closely associated with a number of hearing disorders including noise‐induced hearing loss. Noise trauma disrupts the intra‐strial fluidblood barrier leading to lesions, edema and entry of serum proteins. In this report, we identify down‐regulation of pigment epithelium‐derived factor (PEDF) in perivascular resident macrophages (PVM/Ms), a key factor in intra‐strial fluid‐blood barrier hyper‐permeability. Treatment with PEDF substantially protects against deterioration in barrier integrity, a drop in endocochlear potential and hearing loss in noise‐exposed animals. The PEDF treatment protects by promoting expression of tight junction‐associated proteins and stabilizing PVM/Ms by increasing expression of neural cell adhesion molecules. The dramatic effect of PEDF on barrier integrity suggests new strategies for treatment of acoustic stroke. This work was supported by NIH NIDCD DC008888–02A1 (Shi, X.R), NIH NIDCD DC008888–02S1 (Shi, X.R), NIH NIDCD R01‐DC010844 (Shi, X.R), NIH NIDCD R21‐ DC012398–01 (Shi, X.R), NIH P30‐DC005983.