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The independent and additive effects of yogurt and its probiotics on serum lipid profile: a meta‐analysis and randomised controlled trial
Author(s) -
Lee Ivey Kerry,
Hodgson Jonathan Marcus,
Lewis Joshua Richard,
Kerr Deborah,
Thompson Peter L,
Prince Richard Lewis
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb427
Subject(s) - probiotic , placebo , randomized controlled trial , medicine , lactobacillus acidophilus , fermentation , food science , lipid profile , clinical trial , bacteria , biology , cholesterol , genetics , alternative medicine , pathology
Dyslipidaemia leads to an increased risk of cardiovascular disease. Probiotic yogurt contains both probiotic bacteria and biologically active agents produced during bacterial fermentation of milk. However the effects of products of bacterial fermentation compared to isolated probiotic bacteria on metabolism remain uncertain. Preliminary data from our Cochrane Collaboration approved meta‐analysis of clinical trials have demonstrated that probiotic yogurt and probiotics can reduce total cholesterol by 0.12 mmol/L (P=0.009). Consequently, we undertook a randomized, double‐blinded, parallel, factorial, placebo‐controlled trial of the independent and additive effects of a daily dose of >; 3 × 10 9 of L. acidophilus La5 and B. lactis Bb12 as capsules or as fermented milk. 155 men and women over 55 y with features of metabolic syndrome were randomized to one of four 6 week intervention groups receiving both a dairy product (either yogurt or the placebo milk), and capsules (either probiotic or placebo). Change in serum lipid profile was assessed. The clinical trial is nearing completion, following which the randomization codes will be accessed and results of the clinical trial will be prepared for presentation at the 2013 ASN. By using identical strain and dose of probiotic bacteria, the results of our RCT will directly compare the effect mode of probiotic administration has on lipid outcomes.