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Effect of ketogenic therapy on seizure load score, medication load score, and response score in patients with intractable epilepsy
Author(s) -
Allen Hannah J,
Len Dylan J,
Giurcanu Mihai C,
Borum Peggy R
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb414
Subject(s) - medicine , epilepsy , ketogenic diet , antiepileptic drug , psychiatry
Background The goal of ketogenic therapy (KT) for intractable epilepsy (IE) is to eliminate seizures and the need for medication. Objective Use Seizure Load Score (SLS), Medication Load Score (MLS), and Response Score (RS) to determine response to KT of patients with IE. Methods Seizure variables were ranked (1–5) to determine the Seizure Load (SL). Prescribed antiepileptic drug (AED) dose/kg was divided by the minimum recommended AED dose/kg to determine Medication Load (ML). SLS and MLS represent a % change in SL or ML from baseline (BL) at 100%. RS is the mean of SLS and MLS for specified time periods on KT. SLS, MLS, and RS were determined for patients on KT for the following time periods: 1–3, 3–6, and 6–12 months. Results Patients were stratified using SLS in the table below: Group 1 (SLS 50% better than BL), Group 2 (SLS better than BL, not 50% better), and Group 3 (SLS worse than BL). MLS and RS were determined for each group and time period on KT. Conclusion Patients can be stratified into response groups using SLS. MLS and RS provide additional information about the response to KT so that progress toward eliminating seizures and the need for medication can be assessed. Supported in part by the National Institutes of Health (NIH) and National Center for Research Resources (NCRR) CTSA grant 1UL1RR029890