Premium
Effects of typical Western meal on postprandial arterial stiffness and vasoactive chemicals in patients with chronic kidney disease and Type II Diabetes
Author(s) -
Lombard Joel Robert,
Gregory Sara,
Laro Bree,
Schwarzkopf Cory,
Moraitis Ann Marie,
Hatch Cherise,
Ayvazian Laurel,
Joubert Jyovani,
Matthews Tracey,
Headley Samuel,
Wood Richard J.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb409
Subject(s) - postprandial , medicine , arterial stiffness , endocrinology , type 2 diabetes , meal , cardiology , diabetes mellitus , blood pressure , gastroenterology
The purpose was to evaluate the effect of an 800 kcal meal (carbohydrate:fat:protein = 41:46:13) on postprandial arterial stiffness in patients with CKD and Type II Diabetes (CKD&T2DM) (n=7). Comparisons were made to patients with T2DM only (n=7) and healthy controls (CON) (n=8). Methods Under fasting conditions, arterial stiffness was measured, then an indwelling catheter was inserted and a blood sample was collected. Stiffness was measured/blood collected immediately after the meal and every hour (h) for 4h. Augmentation index normalized to 75 heart beats per minute (Aix75) was used to estimate arterial stiffness. Results Aix75: Decreased from baseline (bl) (17.3 ± 2.5) to 1h (9.3 ± 2.3) returned at h4 p < .05 (pooled time effect). CKD&T2DM and T2DM differed from the CON (26.7 ± 4.1; 17.7± 9.7 vs. −3.65 ± 3.6) p < .05 but not each other (pooled group effect). SBP: CKD&T2DM (131.5 ± 4.8) differed from the CON (114.5 + 3.4) p < .05. The CON and T2DM (121.8 ± 3.7) did not differ, nor did CKD&T2DM and T2DM. DBP: Decreased from bl (74.8 ± 2.2) in h1 and 2 (67.5 ± 2.5; 68.0 ± 2.5) and returned at h4 (73.0 + 2.4) p < .05 in all groups. Nitric oxide: No time or group effect. Endothelin: Was lower in all groups at h3 than at h0, h1, and 2 p < .05. Discussion CKD&T2DM and T2DM patients experience a smaller postprandial reduction in arterial stiffness when compared to healthy CON. Hemodyamics may be a main contributor as illustrated by the trend seen in DBP.