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PEPTIDE VACCINE TO RECOVERY THE SALIVARY GLANDS OF DIABETIC MICE
Author(s) -
Caldeira Eduardo José,
Silva Rodrigo Eduardo,
Dias Marco Antônio,
Mancio Rafael Dias,
Netto Raphael Oliveira,
Rojas Fernanda,
Peroni Luis,
Júnior Rui Seabra Ferreira
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb40
Subject(s) - nod mice , nod , endocrinology , diabetes mellitus , medicine , salivary gland , homeostasis , inflammation , insulin , glucose homeostasis , saline , group a , chemistry , insulin resistance
Current treatments for diabetes, such as insulin, are ineffective to recovery of organs and tissues. Thus, the aim of this study was to evaluate the effects of peptides P217 and P290 in the recovery of salivary glands of diabetic mice. Animals were divided into 3 groups; Group I (7 Balb/C mice), Group II (7 NOD mice), and Group III (7 NOD mice/treated). Group III received the peptides during a total period of 21 days. Groups I and II received saline solution to simulate the experimental treatment. After treatment tissue samples were analyzed by light and fluorescence microscopy. Treated animals consumed less liquid and solid. Reduction of body weight was observed in untreated animals. High levels of glucose were observed in animals of group II, while in treated diabetic animals, a reduction was observed in these levels. Inflammatory process was not observed in group I. Intense inflammatory process was observed in untreated diabetic animals. Reduction of inflammatory process was observed in treated animals. In these animals were observed decrease of lymphocytes and increase of neutrophils. Tissue restructuration was observed after the immunization, as well as was observed the recovery of insulin receptor expression. This treatment was effective in the recovery of salivary cells, contributed to homeostasis of body metabolism and reduction of inflammatory process, that suggest an attempt of tissue reorganization. This immunomodulation promoted a beneficial effect on the recovery of these tissues.