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Alcohol consumption and breast cancer risk by family history of breast cancer and folate intake: A prospective cohort study
Author(s) -
Kim Hyun Ja,
Jung Seungyoun,
Chen Wendy,
Willett Walter C.,
Cho Eunyoung
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb387
Subject(s) - breast cancer , medicine , family history , prospective cohort study , relative risk , cancer , cohort study , obstetrics , population , gynecology , cohort , confidence interval , oncology , environmental health
Objectives To evaluate the association between alcohol consumption and breast cancer risk by family history of breast cancer and folate intake. Methods We followed 90,433 premenopausal women aged 26 to 46 years in the Nurses’ Health Study II who provided alcohol intake data at baseline of 1991. Cumulative alcohol and folate intake was measured by a food frequency questionnaire, which was repeated every 4 years. Results During 18 years of follow‐up, we documented 2,420 incident cases of invasive breast cancer. Alcohol consumption was not significantly associated with breast cancer risk overall. However, when the association was stratified by family history of breast cancer, alcohol consumption was associated with risk of breast cancer among those with a family history of breast cancer in a 1 st degree relative. Compared with non‐drinkers, the multivariate relative risks (RR) of breast cancer for alcohol consumption of ≥ 10g/day was 1.54 (95% confidence interval [CI], 1.09–2.16) among those with family history and 1.01 (95% CI, 0.86–1.18) among those without family history. Among those with positive family history, the positive association was largely limited to those with low folate intake (<400mcg/d) (RR, 2.02; 95% CI, 1.13–3.60 for alcohol consumption ≥ 10g/day vs. non‐drinkers). Conclusions In this population of largely premenopausal women, alcohol consumption was associated with an increased breast cancer risk among those with family history of breast cancer, especially when folate intake was low.