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Elevated leptin concentration is associated with low glucose, high triglycerides, high cholesterol and low HDL concentrations in Mexican women living in rural areas
Author(s) -
Elian Shadia,
Garcia Olga P,
Ronquillo Dolores,
Carmen Caamaño María,
Rosado Jorge L
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb364
Subject(s) - leptin , medicine , endocrinology , waist , dyslipidemia , overweight , population , obesity , lipid profile , cholesterol , environmental health
The objective of this cross‐sectional study was to evaluate the relationship between leptin concentration, fasting glucose and lipid profile in women living in rural Mexico. Weight, height, waist circumference and body composition were measured in 580 women (36.9 ± 7.6 y). A fasting blood sample was taken for the analysis of leptin, glucose and lipid profile. Prevalence of obesity and overweight was 44% and 36%, respectively. 82% of the population had high risk waist circumference (>;80 cm) and 96% had elevated body fat content (>;30%). Leptin concentration was positively associated with BMI, waist circumference and % body fat (p<0.05). Unadjusted regressions showed an inverse association between leptin and HDL cholesterol. In regressions analysis adjusted for body fat percent, BMI and age, an inverse relationship with glucose was found. Women with high levels of triglycerides (>;150 mg/dL), high cholesterol (>;200 mg/dL) and low concentrations of HDL (<50 mg/dL) had significantly higher leptin concentrations (p<0.05) compared with women with adequate lipid profile. In conclusion, higher leptin concentration is associated with low glucose and dyslipidemia and higher risk of heart disease in this population. Supported by CONACYT.