Premium
Effect of lycopene on adipose tissue mass and inflammatory factor in high fat diet‐induced obese
Author(s) -
Choi SooKyong,
Ryu HaeJeong,
Seo JungSook
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb360
Subject(s) - adipose tissue , medicine , endocrinology , lycopene , adiponectin , obesity , lipid metabolism , chemistry , insulin resistance , carotenoid , biochemistry
The present study was performed to investigate the effects of lycopene on adipose tissue mass and inflammatory factor in high fat diet‐induced obese gerbil. Gerbils were randomly divided into a normal diet group, a high fat diet group, lycopene‐supplemented normal diet group, and lycopene‐supplemented high fat group. Epididymal adipose tissue mass higher in high fat diet group than in normal diet group, but it was not affected by lycopene supplementation. Mesenteric fat tissue and brown adipose tissue mass increased by high fat diet but decreased significantly by lycopene supplementation. Concentration of adiponectin was increased in lycopene treatment group when compared with HF group, but the change was not statistically significant. There were no statistically significant differences in plasma level of CRP among the experimental groups. The level of oxidized LDL was increased in high fat diet group compared with in the normal diet group, but it was reduced by lycopene feeding. A significant negative correlation was observed between plasma adiponectin and mesenteric fat tissue. Plasma concentration of ox‐LDL was significantly correlated with epididylmal adipose tissue, brown adipose tissue and mesenteric fat tissue mass. These results suggest that dietary supplementation of lycopene may prevent the chronic diseases related to lipid metabolism through suppression of inflammatory factor.