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Effects of participation in popular weight loss and fitness programs on insulin and leptin in women
Author(s) -
Dalton R,
Lockard B,
Baetge C,
Levers K,
Galvan E,
Jagim A,
Simbo S,
Byrd M,
Jung YP,
Oliver JM,
Koozehchian M,
Khanna D,
Sanchez B,
Kresta JY,
Horrell K,
Leopold T,
Cho M,
Springer S,
Rivera A,
Cerda C,
Rasmussen C,
Kreider R
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb339
Subject(s) - leptin , insulin resistance , medicine , endocrinology , insulin , weight loss , obesity
100 sedentary women (46±11 yr, 45.8±5% body fat, 35.2±5 kg/m2) were randomized to participate in a no diet or exercise control group (C) or the Curves Complete® 90‐day Challenge (CC), Weight Watchers® Points Plus (WW), Jenny Craig® (JC), or Nutrisystem® Advance Select™ (NS) weight loss programs for 12‐wks. Participants in the diet groups were encouraged to exercise (WW, JC, NS) while those in the CC group participated in a structured circuit‐style resistance training (3 d/wk) and walking (3 d/wk) program. Fasting blood samples were obtained at 0, 4, 8, & 12 wks. Changes from baseline to 12‐wks intervention for fasting insulin, the glucose to insulin ratio, homeostatic model assessment (HOMA), and leptin were analyzed by one‐way ANOVA. Participants in the CC group tended to experience greater changes in fasting insulin (C 0.8±6.9; CC −7.5±14; WW − 2.9±8.1; JC −3.8±6.3; NS −1.2±8.3 uIU/ml, p=0.10), the glucose to insulin ratio (C −1.3±4.1; CC 7.0±14; WW 3.3±5.4; JC 4.8±7.4; NS −6.0±21, p=0.01), HOMA (C 0.1±1.6; CC −2.3±4.4; WW − 0.8±1.7; JC −1.0±1.9; NS −0.4±2.2, p=0.07) and leptin (C 4.3±16; CC −17.9±21; WW −13.0±16; JC −12.2±25; NS −3.5±26 ng/ml, p=0.03) compared to some of the other diet and exercise interventions. Results indicate that participation in different diet and exercise programs may have variable effects on markers of insulin resistance and leptin.