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Association of inflammatory markers with cognitive, pain and functionality assessment measures in long term care older adults
Author(s) -
Viveky Navita,
Billinsky Jennifer,
Thorpe Lilian,
Alcorn Jane,
Hadjistavropoulos Thomas,
Whiting Susan
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb323
Subject(s) - medicine , cognition , grip strength , dementia , gerontology , association (psychology) , physical therapy , vitamin d and neurology , cognitive decline , activities of daily living , inflammation , chronic pain , psychology , disease , psychiatry , psychotherapist
Chronic inflammation may promote the development of age related conditions such as dementia, osteoporosis, pain and frailty especially in long term care (LTC) residing older adults. Aim of the study was to determine associations between inflammation and measures of functionality, cognition and pain in LTC residing older adults in Saskatoon, SK Canada. Those 60–80 y residents in LTCs, able to satisfactorily comply with protocol requirements were enrolled. Blood draws (inflammatory cytokines, hs‐CRP, 25(OH)‐vitamin D, cholesterol and prealbumin), vital signs, chart review and functional assessments (cognition, physical functioning, and pain) were done at baseline. Correlational analysis was used to study the relationship of inflammatory markers with the cognitive, functional and pain indices. Adults (n=26; 8 F, 18 M) (mean age 70.7 y) were enrolled. IL‐6 was significantly inversely correlated to all physical functioning measures. hs‐CRP was inversely correlated to cognitive tests (r = −0.54, p < 0.05) and activities of daily living (r = −41, p < 0.05). 25(OH)D was positively correlated to grip strength (r = 0.43, p < 0.05). Pain measures showed no significant correlations. Our results indicate an association of inflammatory markers with functionality tests, particularly grip strength, cognition, and activities of daily living in the LTC residing older adults. SHRF grant to Dr.T. Hadjistavropoulos QOL Team.