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Self‐Reported Dietary Intake and the Human Metabolome
Author(s) -
Guertin K A,
Moore S C,
Sampson J N,
StolzenbergSolomon R Z,
Sinha R,
Cross A J
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb316
Subject(s) - metabolite , metabolome , betaine , metabolomics , chemistry , food science , medicine , oxidative stress , endocrinology , physiology , biology , biochemistry , chromatography
Metabolomics may improve upon self‐reported measures of dietary intake, or offer a substitute when self‐report is unavailable. We investigated partial Pearson correlations between self‐reported diet and ~500 serum metabolites, measured by HPLC and GC‐MS, in 254 adults from a large U.S. cohort. After Bonferroni correction and adjustment for age, gender, smoking, and energy intake, >;43 metabolites were correlated with citrus fruits, seafood, peanuts, coffee, alcohol, calcium, or multivitamins. Serum proline betaine, found in citrus fruits, was correlated with citrus intake (r=0.39). As expected, multivitamins were associated with higher serum α‐tocopherol (r=0.31) and lower γ‐tocopherol (r=−0.26). 3‐Carboxy‐ 4‐methyl‐5‐propyl‐2‐furan propionic acid (CMPF), a uremic toxin which induces oxidative stress in vitro and impedes drug metabolism, was associated with fish intake (r=0.32); CMPF is of unknown origin but has been detected in fish. A further 17 unknown metabolites were associated with diet (r=0.23–0.38); identifying these metabolites may provide insight into downstream effects and diet‐disease associations. Future studies should investigate correlations reported herein, associations of these metabolites with disease, and determine whether dietary and metabolite data can be combined to better characterize associations with disease. Funding: NCI Intramural Research, NIH