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Beneficial effect of blueberry wine on alcoholic fatty liver in rats
Author(s) -
Choi Hansol,
Kim Juyeon,
Park Joonghyeap,
Noh Sang K.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb290
Subject(s) - wine , fatty liver , ethanol , food science , alcoholic fatty liver , berry , cholesterol , liquid diet , chemistry , medicine , biology , biochemistry , botany , disease
Evidence indicates that wines made from berry fruits are beneficial for health. This study was conducted to investigate whether blueberry wine would ameliorate the accumulation of serum and hepatic lipids in ethanol‐induced fatty liver rats. Adult male rats were fed either an ethanol Lieber‐DeCarli liquid diet or an isocaloric control diet or the ethanol diet with blueberry wine. Rats were fed equally their respective diets for 6 wk. Serum triglycerides, total cholesterol (C), HDL‐C, and non‐HDL‐C were determined at 0, 3, and 6 wk. The liver was removed for histology at 6 wk. Blueberry wine administration significantly lowered liver weight, compared to ethanol‐fed rats. Also, blueberry wine significnatly decreased hepatic lipids to the levels of control. These data indicate that blueberry wine protects the liver from fat accumulation induced by ethanol comsumption. This work (Grants No. C0035781) was supported by Business for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 2012.