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Sorghum extract lowers blood and hepatic lipids in rats fed a high fat diet
Author(s) -
Kim Juyeon,
Noh Sang K.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb288
Subject(s) - medicine , endocrinology , blood lipids , sorghum , cholesterol , secretion , chemistry , absorption (acoustics) , biology , agronomy , physics , acoustics
Recently, we have shown that sorghum extract (SE) lowers the intestinal absorption of lipids and also increases their biliary secretion in rats. Further study was conducted to examine if SE would affect blood and hepatic lipids in rats fed a high fat diet for 6 wk. One group of five rats (control) were fed an AIN‐93G diet mixed with 3% (w/v) lard and 0.2% cholesterol (C) and the other with the same control diet but containing SE at 7.5 g/kg diet. Rats had free access to their respective diets over 6 wk. At 0, 3, and 6 wk, serum triglycerides, total C, HDL‐C, and non‐HDL‐C were determined. No difference in bodyweight changes was noted between the groups throughout 6 wk. However, the concentrations of serum triglycerides, total C, HDL‐C, and non‐HDL‐C were significantly lowered in rats given SE. Also, total lipids in the liver of SE rats were significantly lower than control rats. Taken together, these results indicate that SE has a profound inhibitory effect on serum and hepatic lipids by lowering the intestinal absorption of lipids and also enhancing their biliary secretion.