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Preventing iron deficiency: Results of a randomized controlled trial of double‐fortified salt in female Indian tea pluckers
Author(s) -
Hammons Julie,
Venkatramanan Sudha,
Mehta Saurabh,
Haas Jere
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb287
Subject(s) - micronutrient , medicine , context (archaeology) , odds ratio , randomized controlled trial , iron deficiency , logistic regression , ferritin , placebo , psychological intervention , anemia , environmental health , biology , pathology , alternative medicine , paleontology , psychiatry
Previous research has shown that consuming iron‐fortified salt improves iron status. The present analyses examined predictors of the prevention of iron deficiency (ID) during a randomized, double‐blinded, placebo controlled intervention of double‐fortified salt (DFS). Participants were 217 female tea pluckers, aged 19–55 years, from West Bengal, India. Mixed models were used to assess the effect of DFS on the change in baseline iron status and other micronutrient indicators (iodine, folate, vitamin B 12 ). Predictors of ID incidence were identified using logistic regression models. DFS significantly decreased the odds that women who had normal iron status at baseline would develop moderate or clinical ID (ferritin <20 or 12 μg/mL, respectively). Higher hemoglobin and lower transferrin receptor concentrations at baseline also predicted lower odds of developing ID or moderate ID. The results are discussed in the context of designing interventions in multiple‐micronutrient‐deficient settings and may help identify populations likely to benefit from future efficacy and effectiveness trials of dietary iron interventions. Supported by the Mathile Institute and the Micronutrient Initiative.