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Vitamin D supplementation for four months causes cardiac hypertrophy and diastolic dysfunction in normal rats
Author(s) -
Santos Priscila Portugal,
Rafacho Bruna,
Gonçalves Andréa,
Cândido Renata,
Ferreira Vanessa,
Roscani Meliza,
Minicucci Marcos,
Campana Alvaro,
Zornoff Leonardo,
Gaiolla Paula,
Paiva Sergio
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb281
Subject(s) - ventricle , medicine , vitamin d and neurology , cholecalciferol , diastole , vitamin , cardiac hypertrophy , endocrinology , muscle hypertrophy , cardiology , blood pressure
The aim of the study was to evaluate different vitamin D supplementation doses in the cardiac structure and function in normal rats. Methods 46 male rats allocated into 3 groups: control (C, n=14) received standard chow; D3 (n=16) and D10 (n=16) received 3,000 and 10,000 IU of cholecalciferol/kg chow for 4 months, after was performed echocardiography evaluation and morphometry. Results The posterior wall thickness (C=1.3(1.3–1.5); D3=1.8(1.8–2.0); D10=1.8(1.7–1.8) mm; p<0.001), relative wall thickness (C=0.39±0.04; D3=0.52±0.09; D10=0.50±0.06; p<0.001) and left ventricle mass/weight body (WB)(C=1.6±0.2; D3=2.0±0.3; D10=2.0±0.4 mg/g; p<0.001) were higher in supplemented groups compared to C. The supplemented animals presented higher left atrial diameter/aortic diameter (C=1.1±0.1; D3=1.4±0.2; D10=1.3±0.2; p<0,001). The worst diastolic dysfunction was in D10, which led to lower values of tricuspid E/A‐wave ratio (C=0.66(0.57–1.28); D3=0.58(0.52–0.71); D10=0.53(0.47–0.60); p=0.04) and higher values of right ventricle weight/WB(C=0.46±0.03; D3=0.46±0.03; D10=0.50±0.05 mg/g; p=0.014) compared to C. Conclusion Normal rats supplemented with vitamin D showed concentric cardiac hypertrophy and diastolic dysfunction with impaired right side heart in animals supplemented with the highest dose.