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Protective effect of Cirsium setidens extract against the alcohol‐induced liver injury in rats
Author(s) -
Kim Eunhye,
Chung Jayong
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb267
Subject(s) - steatosis , alcohol , ethanol , liver injury , inflammation , endocrinology , medicine , fatty liver , chemistry , liquid diet , alcoholic fatty liver , fatty acid synthase , pharmacology , biochemistry , lipid metabolism , disease
Cirsium setidens is a medicinal herb that is rich in flavonoids. The aim of this study was to determine the effect of Cirsium setidens ethanol extract (CSE) against the alcohol‐induced liver injury in rats. Sprague‐Dawley rats were fed a Lieber‐DeCarli liquid diet with either alcohol alone, alcohol +100 mg/kgBW CSE, or alcohol + 500mg/kgBW CSE for 2 months. Control rats were fed the same amount of isocaloric liquid diet without alcohol. Chronic alcohol feeding resulted in the development of hepatic steatosis, and significantly increased the levels of ALT and AST in the serum, as compared with controls. The alcohol‐induced steatosis was associated with the up‐regulation of fatty acid synthase ( FASN ) gene expression. Further, alcohol feeding greatly stimulated the hepatic NF‐κB signaling pathway, a master regulator of inflammation. In contrast, CSE supplementation in alcohol‐fed rats ameliorated hepatic steatosis, and restored the levels of serum ALT and AST to control levels. Moreover, the CSE supplementation significantly blocked the alcohol‐induced hepatic FASN gene expression in a dose‐dependent manner. In addition, the CSE supplementation markedly suppressed the activation of NF‐κB in the liver tissues of alcohol‐fed rats. In summary, our study results suggest that CSE protects against alcohol‐induced liver injury, via the suppression of fatty acid synthesis and inflammation.