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AssuriTEA® Wellbeing Improves Antioxidant Status in Healthy Male Subjects
Author(s) -
Capodice Jillian,
Herrlinger Kelli,
Chirouzes Diana,
Katz Aaron,
Ceddia Michael
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb266
Subject(s) - placebo , tolerability , antioxidant , medicine , blood pressure , randomized controlled trial , endocrinology , adverse effect , chemistry , biochemistry , pathology , alternative medicine
Green and black teas have known anti‐oxidant and anti‐inflammatory properties. The aim of this randomized, doubleblind, placebo‐controlled clinical trial was to evaluate the effect of a water‐extracted green and black tea blend (AssuriTEA® Wellbeing [ATW]) on serum antioxidant status, vital signs, and tolerability in healthy males. Men, ages 25–70, were randomized to receive placebo, 250 mg, 500 mg, or 1000 mg ATW daily for 28 days. At baseline (BL) and day 28, serum antioxidant capacity was evaluated through ferric iron reducing antioxidant power (FRAP) and cellular antioxidant protection (CAP‐e). Forty‐three subjects were evaluable (>;80% compliant). Subjects (56.8 ± 2.8 years [mean ± SEM]) demonstrated improved antioxidant status as measured by FRAP at all doses vs. placebo (p < 0.05). CAP‐e was improved (p = 0.032) at 1000 mg ATW dose vs. placebo. At day 28, fasting serum glucose levels were significantly higher in the placebo group vs. 250 mg ATW (p = 0.023) with a trend observed at 1000 mg ATW (p=0.054). There was a significant improvement in systolic blood pressure (BP) in 250 mg ATW at day 28 vs. BL (p = 0.048). In the 1000 mg ATW, there was a significant decrease in systolic BP and a trend toward decrease in diastolic BP at day 28 vs. BL (p = 0.017, p = 0.067). There were no abnormal changes in hematology or hepatic function. ATW was well tolerated and resulted in improved serum antioxidant status, blood glucose and systolic BP.