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LC‐MS plasma biomarkers associated with weight loss over 24 months following Roux‐en‐Y gastric bypass surgery
Author(s) -
Bowers Jeremiah,
LeGreve Tracy,
GletsuMiller Nana
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb112
Subject(s) - gastric bypass surgery , endocrinology , betaine , metabolite , medicine , valine , chemistry , glutamine , weight loss , obesity , gastric bypass , amino acid , biochemistry
Objective To observe global changes in plasma metabolic profiles of patients following Roux‐en‐Y gastric bypass (RYGB) surgery. Method Plasma global metabolite profiles from patients that were monitored before 6 months (n=13) and 24 months (n=5) following RYGB were determined using high performance liquid chromatography‐mass spectrometry (HPLC‐MS). Fat mass and dietary intake were assessed using air displacement plethysmography and 3‐day dietary records. Data analysis included repeated measures analysis of variance and Pearson correlations, (p < 0.05). Results During 6 months following surgery levels of 3‐indoleacetic acid and proline betaine increased while (9R,13R)‐1a,1b‐dihomo‐jasmonic acid, acetoacetic acid, L‐valine, and choline decreased. Over 24 months, DL‐2‐aminooctanoic acid increased. No cross‐sectional associations were found between metabolites and fat mass, dietary fat, dietary carbohydrate, dietary protein, or daily caloric intake. Conclusions Changes in plasma metabolic profiles following RYGB suggest a metabolic response unrelated to changes in adiposity or macronutrient intake. The impact of specific foods will be investigated further.