Premium
Association of gestational diabetes mellitus with occurrence of Autism: A Cohort Study
Author(s) -
AlFarsi Yahya M,
AlKhaduri Maha,
AlSumri Hanaa,
AlFarsi Omar,
AlSharbati Marwan,
Waly Mostafa,
Ouhtit Allal,
AlShafaee Mohammed
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.lb111
Subject(s) - gestational diabetes , medicine , hazard ratio , confounding , obstetrics , cohort study , diabetes mellitus , proportional hazards model , cohort , population , autism , pregnancy , pediatrics , gestation , confidence interval , environmental health , endocrinology , psychiatry , biology , genetics
Background Several antenatal and perinatal adverse events have been reported to be potentially associated with increased risk of occurrence of autism spectrum disorder (ASD). Among these is the gestational diabetes mellitus (GDM). Objectives To evaluate the potential association between GDM and ASD. Methods A retrospective cohort study has been nested on a community trial titled as “Delaying the Development of Diabetes Mellitus type 2 (AMAL study)” in Oman. The study population included 532 women with a total of 3,196 pregnancies. Multi‐variate Cox proportional hazard regression analyses were conducted to explorer the association between GDM and ASD, adjusting for important confounders. The main outcome measure was hazard ratio (HR) of the effect of GDM on ASD. Results A total of 42 ASD cases have been enumerated over 3714 person‐years of follow up. In the crude model, pregnancies complicated with GDM carried a higher risk of ASD children than pregnancies without GDM (HR = 2.3; 95% CI = 1.5, 3.4). the adjusted model, the association persisted even with control of the confounding effect of maternal age (HR = 1.71; 95% CI = 1.1, 2.3). Conclusion This study provides a supportive evidence that GDM may carry an increased risk of occurrence of ASD. It calls for more strict control of GDm, especially that diabetes mellitus and obesity have reached alarming epidemiologic rates in Oman and the region.