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Role of Salicylic acid in Chromatin Modification and Remodeling
Author(s) -
Kumar Dhirendra,
Haq MD Imdadul,
Hotz Tazley A,
Hossain Mir A,
Zhao Bingqing,
Donald David
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.969.6
Subject(s) - acetylation , salicylic acid , chromatin , histone deacetylase , histone , epigenetics , gene silencing , chromatin remodeling , biology , systemic acquired resistance , histone acetyltransferase , arabidopsis , gene , gene expression , psychological repression , microbiology and biotechnology , biochemistry , mutant
SABP2 is a 29 kDa tobacco protein which catalyzes the conversion of methyl salicylate into salicylic acid (PNAS 2005). RNAi silencing of SABP2 makes the plants more susceptible to pathogens and they fail to exhibit robust systemic acquired resistance (SAR) response (PNAS, 2005). Pathogen induced MeSA being lipid mobile quickly travels throughout the plant and also to neighboring plants. In uninfected tissues, MeSA is converted back to SA by SABP2 to induce SAR (Science, 2007). Using yeast two‐hybrid screening a number of putative SABP2 interactors were identified. One of the putative SABP2 interactor shows similarity to Histone deacetylases (HDAC). HDAC catalyze deacetylation of acetylated proteins. Acetylation and deacetylation have been implicated in chromatin modifications causing epigenetic changes in gene expression. Acetylation of histones is associated with increased transcriptional activity while deacetylation results in repression. HDAC are regulated by salicylic acid suggesting a direct role in biotic stress. HDAC suppress expression of several genes associated with SA biosynthesis in Arabidopsis. Pathogens target the expression of HDAC to suppress expression of host defense genes. Understanding these biochemical pathways would help in developing crop plants with better disease resisting capabilities. This research is supported by a grant from National Science Foundation.