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The influence of dentition on the developing mandible in a mouse model
Author(s) -
Holmes Megan Anne
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.963.7
Subject(s) - molar , dentition , mandible (arthropod mouthpart) , mandibular first molar , mutant , orthodontics , dentistry , biology , anatomy , medicine , genetics , zoology , gene , genus
Developing dentition is considered an important influence on mandibular size and shape. Previously, it was shown that mandibular size and shape was affected in mice carrying an Fgfr2 C342Y/+ mutation, specifically in the ramus rather than alveolar region. Here it is hypothesized that molar size will have a more significant correlation with size and shape of the mandibular alveolar region compared to the ramal region throughout ontogeny. Micro‐CT scans of adult (n=20), perinatal (n=9) and prenatal (n=9) wildtype and mutant mice were used to reconstruct total molar surface area and to collect 3‐D landmark data. Shape and size analyses for each region were conducted using EDMA. Partial correlations were used to test the influence of molar size. Results partly support the stated hypotheses. Principle coordinate plots demonstrate a clear separation in both alveolar and ramal shape between mutant and wildtype mice at each age range. Comparisons of geometric mean using t‐tests reveal that ramal size is significantly smaller in prenatal and adult mutants (p<0.05) but not in the alveolar region (p>;0.05). Partial correlations did not suggest that molar size had a stronger influence on alveolar regions. In conclusion, the alveolar region is less affected than the ramus, however it is not clear whether the dentition is driving this regional difference. It is possible that other ontogenetic factors are masking this signal. Grant Funding Source : NSF