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Factors influencing blood pressure and sympathetic nerve activity during a high fat diet in rabbits
Author(s) -
Head Geoffrey A,
Burke Sandra L,
Barzel Benjamin,
Eikelis Nina,
Lim Kyungjoon,
Armitage James A
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.955.20
Subject(s) - postprandial , medicine , endocrinology , blood pressure , insulin , leptin , heart rate , meal , obesity
Short‐term consumption of a high fat diet (HFD) by rabbits results in increased blood pressure (BP), heart rate (HR) and renal sympathetic activity (RSNA) at a time when adiposity is increased. It is unclear how the HFD‐induced changes in circulating insulin, glucose and leptin contribute to these cardiovascular effects. Rabbits were meal‐fed a 13.5% HFD and BP, HR and RSNA were measured in the home cage daily for 3 weeks via implanted telemeters. Plasma insulin, leptin and blood glucose concentrations were measured weekly. Baseline BP, HR and RSNA over 24h were 70±1mmHg, 205±4b/min and 7±1nu. Within 2 days of commencing a HFD, values increased by 2%,18% and 22%. BP and RSNA increased further over 3 weeks due to elongation of the postprandial phase. Thus, the changes from preprandial minimum to postprandial maximum of 4±1mmHg, 51±6b/min and 1.5±1nu were reduced by 79–127% and were associated with elevated insulin, leptin and glucose. Linear regression indicated all were strong predictors, as well as bodyweight, of HFD‐induced changes to the circadian pattern of HR, BP and to a lesser extent RSNA. In conclusion, elevation in BP, HR and RSNA occur in the first few days of a HFD due mainly to maintenance of post‐prandial increases. Increased plasma insulin, glucose and leptin are predictors of the early cardiovascular effects of a HFD. Supported by grants from National Health and Medical Research Council of Australia.