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Saline loading does not change renal medullary blood flow in essential hypertension
Author(s) -
Assersen Kasper Bostlund,
Gam Jens Christian,
Damkjær Mads,
Valentin Sara,
Olsen Michael Hecht,
Diederichsen Axel,
HøilundCarlsen Poul Flemming,
Bie Peter
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.955.13
Subject(s) - natriuresis , saline , essential hypertension , renal blood flow , medullary cavity , renal circulation , medicine , endocrinology , excretion , blood flow , blood pressure , chemistry
In essential hypertension (EH), the natriuresis during saline loading is exaggerated. It was hypothesized that this phenomenon is associated with an increase in renal medullary blood flow. Patients (n=6) with mild, monosymptomatic EH were investigated after an 18‐d drug washout period including 4 d on standardized diet. Regional, renal blood flows were determined before and after saline loading (0.72 mmol/kg/h for 4 h) by Positron Emission Tomography and Computer Tomography (PET/CT) using H 2 15 O tracer (Am J Physiol Regul Integr Comp Physiol 299:R1449, 2010). Renal medullary blood flows (ml/(g tissue)/min) were 2.0 ±0.4 and 1.7 ±0.3* before and after saline loading, respectively. During saline loading BP (mmHg) changed from 147.6/86.1 ±6.5/3.1 to 157.1*/92.1 † ±4.4/3.3. Renal sodium excretion (μmol/min) increased from 39.2 ±7.0 to 145.6 ±38.5 † . It is concluded that the increase in renal sodium excretion during saline loading is not associated with an increase in renal medullary blood flow. *(P = ns) † (P < 0.05) Funded by The Danish Heart Foundation and The University of Southern Denmark.