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Positive association between physical activity and bone in children with Prader‐Willi Syndrome
Author(s) -
Duran Andrea Tiana,
Castner Diobel Mendoza,
Tucker Jared M,
Rubin Daniela A
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.941.1
Subject(s) - medicine , bone mineral , bone mineral content , fat mass , lean body mass , obesity , body fat percentage , bone health , physical activity , endocrinology , dual energy x ray absorptiometry , dual energy , physical therapy , body weight , osteoporosis
Prader‐Willi Syndrome (PWS) presents hypotonia, congenital obesity, and low lean mass; perhaps leading to less physical activity (PA) and poor bone health. Purpose To explore associations between PA and bone in children with PWS, accounting for body fat. Nine boys and 9 girls with PWS participated (mean age: 11.0±2.2 y, body fat: 46.2±8.5 %). PA was assessed by accelerometry (minimum of 3 compliant weekdays and 1 compliant weekend day) and classified into moderate (MPA), vigorous (VPA), and moderate plus vigorous (MVPA). Fat mass, bone mineral content (BMC), bone mineral density (BMD), and BMD z‐score (BMDz) of the hip and full body minus the head (body) were measured by dual energy x‐ray absorptiometry. MPA was associated with hip BMD and BMDz (r=0.595, r=0.650, respectively). VPA was associated with hip BMC and BMD (r=0.589, r=0.592, respectively) and body BMC and BMD (r=0.549, r=0.572, respectively). MVPA was associated to hip BMC, BMD and BMDz (r=0.523, r=0.653, r=0.607, respectively), and body BMC, BMD and BMDz (r=0.518, r=0.555, r=0.638, respectively). Associations were significant at p<0.05. MVPA had moderate positive associations with all bone parameters. Both MPA and VPA were independently associated with bone. However, VPA showed stronger associations with BMC than MPA. As in other children, intensity of PA appears an important determinant of bone health. Supported by USAMRAA Award W81XWH‐09–1‐0682