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Psycho‐Physiological Changes in Mouse Strain Submitted to Social Stress
Author(s) -
Jibitu Meskerem
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.936.11
Subject(s) - ethogram , social stress , stress (linguistics) , physiology , strain (injury) , psychology , body weight , jumping , biology , endocrinology , anatomy , developmental psychology , zoology , linguistics , philosophy
Three different mouse strains of C57BL/6j, BABLB/cj and DBA/2j were submitted to 10 day and 5 day aggressor exposed (Agg‐E) stress. Mice were kept inside an aggressor (Agg ) home cage and randomly exposed to the Agg three times a day for one minute or up to ten attacks while the controls never experiences the Agg. The ethogram of the Agg‐E stress evaluated by a situation reminder study was analyzed immediately post stress and after a pre‐determined rest period. C57BL/6j, BABLB/cj and DBA/2j displayed noticeable changes in behavioral parameters such as jumping, fighting‐back, grooming, tail rattling and freeze motion when exposed to (Agg ) mice for 5‐ or 10‐day. Strain‐wide physiological alteration was evaluated in body weight, body temperature changes and urine marking; a sign of territorial behavior. Situation reminder evaluated a cluster of traits simulating post‐traumatic stress disorder. Three strains responded differently to a contextual stress 1day and 1.5 weeks post 5‐day social stress, and 1 day and 6 weeks post 10 day social stress. Final result indicate, that DBA/2j and BALB/cj is most resilient and vulnerable to Agg‐E stress, respectively. C57BL/6j displayed a modest change in phenotype character primarily after 10‐day stress. Data analyses of psychological and physiological results were calculated using EthoVision and Graph Pad prism software.